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PP2A Inhibitor II, GST-Fusion, Human, Recombinant, E. coli
Protein Phosphatase 2A Inhibitor II, I2PP2A
Recombinant, human PP2AI I2 fused to GST and expressed in E. coli. Inhibits protein phosphatase 2A (PP2A) potently with Ki ~ 25-30 nM with myelin basic protein, histone H1, and other substrates of PP2A but not with casein as a substrate. Stimulates PP1. Prevents inhibition of E-Cdk-2 by p21Cip1. Associates with B cyclin. Regulates histone binding to DNA, transcriptional activity and chromatin condensation. Undergoes phosphorylation in cells. Highly expressed in some cancers. Associates with HRX leukemia-associated fusion proteins. Occurs as fusion protein in acute undifferentiated leukemia. Does not inhibit PP1, PP2B, PP2C, or pyruvate dehydrogenase.
产品信息
Form Liquid
Formulation In 50 mM Tris-HCl, 14 mM βME, 1 mM benzamidine, 1 mM EDTA, 0.1 mM PMSF, 10% glycerol, pH 7.4.
Primary Target PP2A
Primary Target Ki 25-30 nM
Molar mass 67000
Avoid freeze/thaw 是的
Purity ≥90% by SDS-PAGE
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Standard Handling |