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产品信息
Purity ≥95% by HPLC
Chemical formula C29H39N3O5
Storage -20°C
Peptide Sequence Z-Leu-Leu-Phe-CHO
Form White lyophilized solid
Primary Target MPC
Primary Target Ki 460 nM
Protect from Moisture 是的
Cell permeable 是的
Reversible 是的
A potent, cell-permeable, and reversible proteasome inhibitor. Inhibits the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (MPC; Ki = 460 nM). Does not inhibit the peptidyl-glutamyl peptide hydrolyzing activity of MPC even at concentrations of 200 µM. Also blocks the decay of IκB-α and IκB-β proteins in exponentially growing WEHI 231 cells. |