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PAR-2 Agonist I
Proteinase Activated Receptor-2 Agonist I, 2f-LIGRL-amide
The native PAR-2-specific agonist, SLIGRL-NH2, is modified with an N-terminal furoyl group to increase its potency and resistance to metabolic degradation. Shown to activate [Ca2+]i mobilization in PAR-2-expressing cells (EC50 = 253 nM using HCT-15 cells) in vitro and induce PAR-2 mediated salivation (ED50 = 30 nmol/kg, i.v.) in vivo, while exhibiting no effect on PAR-2-/- mice. Reactive towards human, rat, and murine PAR-2.
产品信息
Peptide Sequence 2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH2
Form White lyophilized solid
Formulation Supplied as a trifluoroacetate salt.
Molar mass 663.8
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C31H53N9O7
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |