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PARP Inhibitor XIV
4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
产品信息
Form Orange solid
Molar mass 252.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC (sum of two isomers)
Solubility DMSO
Chemical formula C15H12N2O2
CAS number 1104546-89-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |