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PARP Inhibitor XI, DR2313
2-Methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]pyrimidine-4-one
This product has been discontinued.
A brain-permeable and water soluble pyrimidinone compound that acts as a potent and NAD+-competitive inhibitor of PARP (IC50 = 200 nM and 240 nM for rhPARP1 and rmPARP2, respectively) with little activity against the dehydrogenase activity of GAPDH, ADH, LDH, or the ADP-ribosylase activity of bacterial diphtheria toxin even at concentrations as high as 10 µM. Shown to inhibit H2O2-induced PAR formation and neuronal cell death in primary rat cerebral cortex culture in vitro (EC50 = 270 nM) and exhibit neuroprotective effects in both permanent and transient focal ischemia models in rat in in vivo.
产品信息
Form White solid
Molar mass 182.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility H2O
Chemical formula C8H10N2OS
CAS number 284028-90-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant |