Polo-like Kinase Inhibitor IV, SBE13 N-(4-((6-Chloro-3-pyridinyl)methoxy)-3-methoxybenzyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)amine A cell-permeable vanillin-derived pyridyl-ethanamine compound that acts as a highly potent type II Plk1 inhibitor (IC50 of 200 pM) and targets the less conserved DFG motif that is only accessible when the kinase is in its inactive DFG-out conformation, resulting in an excellent selectivity over Plk2 (IC50 >66 µM), Plk3 (IC50 = 875 nM), and aurora A kinase (no detectable effect). Shown to inhibit the proliferation of HeLa cells with an EC50 of 18 µM. 产品信息 Form Beige solid Molar mass 442.9 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥94% by HPLC Solubility DMSO Chemical formula C24H27ClN2O4 CAS number 775294-82-1 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling