PI 3-K Inhibitor XI, HWT

PI 3-K Inhibitor XI, HWT
Wortmannin, 17β-Hydroxy, LY 301497, mTOR Inhibitor VIII
A cell-permeable Wortmannin (Cat. Nos. 681675 and 681676) 17β-Hydroxy analog (HWT) that acts as an irreversible PI 3-K inhibitor with an 8.4-fold higher potency than that of Wortmannin (IC50 = 0.5 and 4.2 nM, respectively) and inhibits mTOR only at much higher concentrations (IC50 = 0.193 µM). Both Wortmannin and HWT covalently modify a conserved lysine residue (Lys833 in porcine PI 3-Kγ) in the PI 3-K ATP binding pocket via their electrophilic furan ring at C-20 position. HWT is shown to effectively arrest the growth of LNCaP cells (IC50 = 1.464 µM) in vitro, however, its high in vivo toxicity renders it unsuitable for tumor killing studies in mice. Also reported to inhibit late phase PLD-mediated PA production upon fMLP (Cat. No. 05-22-2500) stimulation of human neutrophils.
产品信息
Form  Off-white solid
Molar mass  430.5
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO
Chemical formula  C23H26O8
CAS number  58053-83-1
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling