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Phenylarsine Oxide
PAO, Oxophenylarsine, PDI Inhibitor II, Protein Disulfide Isomerase Inhibitor II, PTP Inhibitor IX
A membrane-permeable protein tyrosine phosphatase inhibitor (IC50 = 18 µM). Stimulates 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates p56lck protein tyrosine kinase. Blocks TNF-α-dependent activation of NF-κB in human myeloid ML-1a cells. PAO inhibits the protease activities of recombinant human caspases as well as endogenous caspases that are active in extracts of pre-apoptotic chicken DU249 cells (S/M extracts).
产品信息
Form White solid
Molar mass 168.0
Purity ≥96% by titration
Solubility CHCl3 or DMSO
Chemical formula C6H5AsO
RTECS CH8100000
CAS number 637-03-6
Merck USA index 14, 6949
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +15°C to +30°C
Ship Ambient Temperature Only
Highly Toxic & Carcinogenic / Teratogenic |