P53 MODULATOR, CP-31398

p53 Modulator, CP-31398
N′-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl, p53 Activator V
A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation as determined by mAb PAb1620 (Cat. No. OP33) reactivity and DNA binding in both intact cells and in cell-free assays. Shown to induce p21WAF1 and Bax expressions and apoptosis (2.5 to 10 µg/ml) in mutant p53-carrying, but not p53-null, cells. Reported to suppress the growths of human cancer cells, A375-S2 and DLD-1, in mice (100 mg/kg/day; i.p.) and Azoxymethane-induced colorectal cancer in F344 rats (supplemented at 100 to 400 ppm in animal feed) in vivo. Unlike PRIMA-1 (Cat. No. 530050), CP-31398 directly targets the DBD (DNA binding domain) of p53. Also known to induce p53-independent cytotoxicity in cultures at concentrations above 15 µg/ml.
产品信息
Form  Yellow solid
Molar mass  435.4
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥90% by HPLC
Solubility  DMSO
Chemical formula  C22H26N4O • 2HCl
CAS number  259199-65-0
商店和运输信息
Storage  -20°C
Ship  Dry Ice Only
Standard Handling