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p38 MAP Kinase Inhibitor IV
2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
产品信息
Form Light yellow solid
Molar mass 456.9
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C12H4Cl6O4S
CAS number 1638-41-1
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful |