P21-ACTIVATED KINASE INHIBITOR, PAK18

p21-Activated Kinase Inhibitor, PAK18
H2N-RKKRRQRRR~G~PPVIAPRPEHTKSVYTRS-CO2H, PAK Inhibitor I
A PAK (p21-activated kinase) inhibitor peptide that is composed of the cell permeant TAT peptide sequence and an 18-mer Pro-rich PIX-interacting motif of PAK that disrupts PIX-PAK interaction, reduces cellular PAK phosphorylation, and induces neurodegenerative morphology in hippocampal neurons in vitro. Intracerebroventricular administration of PAK18 in mice resulted in Alzheimer-like disease phenotype in vivo. PIX-interacting motif sequence has also been shown to block ras-dependent tumor growth and PAK activation in NIH-3T3 cells. The inactive control peptide, PAK18-R192A, is also available (Cat. No. 506102).
产品信息
Peptide Sequence  H-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly~Pro-Pro-Val-Ile-Ala-Pro-Arg-Pro-Glu-His-Thr-Lys-Ser-Val-Tyr-Thr-Arg-Ser-OH
Form  Lyophilized
Formulation  Supplied as trifluoroacetate salt
Molar mass  3413.9
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO or H2O
Chemical formula  C146H254N58O37
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling