正品|(5Z)-7-OXOZEAENOL, CURVULARIA SP.

产品说明
A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.
产品信息 
Form  White solid 
Protect from Light  是的 
Packaged under inert gas  是的 
Purity  ≥97% by HPLC 
Chemical formula  C19H22O7 
CAS number  66018-38-0
Storage  -20°C 
Ship  Shipped with Blue Ice or with Dry Ice
Standard Handling