产品说明 A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative (ED50 = ~ 2.7 µg/ml in lymphoid malignant cells) and antiangiogenic properties (significantly inhibits network formation of HMEC-1 cells at 2.5 µg/ml). Reported to affect DNA synthesis, induce apoptosis and initiate cell cycle arrest. Shown to efficiently block both TNF-α and LPS-induced NF-κB activity in Jurkat and in RAW264.7 murine macrophages, and inhibit p65 NF-κB transcriptional activity (IC50 = ~ 5 µg/ml in MT-1 cells) by disrupting NF-κB DNA-binding activity without interfering with its nuclear translocation. 产品信息 Form Yellow solid Primary Target NF-κB transcriptional activity Primary Target IC50 5 µg/ml in MT-1 cells Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Chemical formula C20H28O6 RTECS NZ8177000 CAS number 28957-04-2 Storage -20°C Ship Shipped with Blue Ice or with Dry Ice Standard Handling