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Olomoucine
2-(2-Hydroxyethylamino)-6-benzylamino-9-methylpurine
A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available.
产品信息
Form Crystalline solid
Primary Target p34cdk1/cyclin B
Primary Target IC50 7 µM
Secondary target p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), p44 MAP kinase (IC50 = 25 µM), p34cdk4/cyclin D (IC50 > 1 mM), p40cdk6/cyclin D3 (IC50 > 250 µM)
Molar mass 298.3
Purity ≥98% by TLC
Solubility DMSO
Chemical formula C15H18N6O
CAS number 101622-51-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |