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Okadaic Acid, Prorocentrum sp.
An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50 = 10-15 nM) and protein phosphatase 2A (IC50 = 0.1 nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. A 250 µM (25 µg/124 µl) solution of Okadaic Acid, (Cat. No. 495609) in DMSO is also available.
其他选项
459616 Okadaic Acid, Ammonium Salt
459620 Okadaic Acid, Sodium Salt
459618 Okadaic Acid, Potassium Salt
产品信息
Form Colorless glassy solid
Primary Target protein phosphatase
Primary Target IC50 10-15 nM
Secondary target protein phosphatse 2A (IC50 = 0.1 nM)
Molar mass 805.0
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility MeOH, EtOH, DMF, CHCl3
Chemical formula C44H68O13
RTECS AA8227800
CAS number 78111-17-8
Merck USA index 14, 6819
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Ship Ambient Temperature Only
Toxic |