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产品信息：
Form Light yellow powder
Primary Target (NO)-sensitive guanylyl cyclase
Primary Target IC50 20 nM
Protect from Light 是的
Cell permeable 是的
Purity ≥98% by TLC and HPLC
Chemical formula C9H5N3O2
CAS number 41443-28-1
Storage -20°C
Ship Ambient Temperature Only
Irritant
产品说明：
A cell-permeable, potent and selective inhibitor of nitric oxide (NO)-sensitive guanylyl cyclase (IC50 = 20 nM). In incubated cerebellum slices, ODQ reversibly inhibits the NO-dependent cGMP response to glutamate receptor agonists without affecting NOS activity. It does not chemically inactivate NO; however, it does inhibit cGMP generation in response to NO donors. ODQ does not inhibit NO-mediated macrophage toxicity, a phenomenon unrelated to cGMP, nor does it affect the activity of particulate guanylyl cyclase or adenylyl cyclase. |