Nifuroxazide 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3. 产品信息 Form Bright yellow solid Molar mass 275.2 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C12H9N3O5 CAS number 965-52-6 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling