产品信息 A cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α), a nonapoptotic necrotic cell death pathway mediated by death-domain receptors (DRs) that offers neuroprotection in a murine model of ischemic brain injury. Exhibits no effect on DR-induced apoptosis. Also acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity. Nec-1 target appears to be a critical common necroptotic step upstream of execution events and downstream of DRs. Inactive control, Nec-1i, is also available (Cat. No. 480066). CAS number 4311-88-0 Storage +2°C to +8°C Form Yellow crystalline solid Primary Target necroptosis Primary Target IC50 EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α Protect from Light 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Chemical formula C13H13N3OS