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MK-2 Inhibitor III
2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
A cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
产品信息
Form Pale yellow solid
Molar mass 358.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C21H16N4O • H2O
CAS number 1186648-22-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |