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MG132是一种蛋白酶体抑制剂，抑制蛋白的降解，保存在-20度，避光.
A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available.
Product information
Peptide Sequence Z-Leu-Leu-Leu-CHO
Form White solid
Primary Target proteasome
Primary Target Ki 4 nM
Secondary target NF-κB (IC50 = 3 µM)
Molar mass 475.6
Cell permeable Yes
Reversible Yes
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C26H41N3O5
CAS number 133407-82-6 |