Membrane Traffic Inhibitor, A5 1-(4-(4-(E-2-Methyl-2-butenyl)piperazinyl)phenyl)ethanone, HCl, 5431942, A5 A cell-permeable piperazinyl compound that specifically blocks clathrin adaptor complex AP-1-dependent traffic between trans-Golgi network (TGN) and endosomes in budding yeast, while exhibiting little effects against other trafficking pathways involving TGN and endosomes. Inhibits growth of yeast cells lacking complementary GGA1/2 adaptor proteins (EC50 = 50 µM), but not wild-type or AP-1-deficient cells even at concentrations as high as 300 µM. A5 presumably acts at a stage after AP-1 membrane recruitment as evidenced by an enhanced AP-1 perinuclear localization upon A5 treatment of HeLa cells. 产品信息 Form Pale yellow solid Molar mass 308.9 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility H2O Chemical formula C17H24N2O • HCl 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling