产品信息 Form Yellow to brown solid Primary Target FTAse Primary Target IC50 5 mM Secondary target geranylgeranyltransferase I (GGTase I; IC50 = 180 mM), farnesylpyrophosphate (FPP; Ki = 1.2 mM) Protect from Light 是的 Purity ≥96% by HPLC Chemical formula C31H38N2O7 CAS number 52665-74-4 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling 产品说明 An antibiotic with antitumor properties. A cell-permeable potent and selective inhibitor of farnesyltransferase (FTase; IC50 = 5 µM) compared to geranylgeranyltransferase I (GGTase I; IC50 = 180 µM). Manumycin acts as a competitive inhibitor of FTase with respect to farnesylpyrophosphate (FPP; Ki = 1.2 µM), but acts as a noncompetitive inhibitor with respect to the Ras acceptor protein. Reported to inhibit the growth and invasive activity of pancreatic cancer cells.