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440202 LY 294002
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
Product information
Form Off-white solid
Primary Target specific phosphatidylinositol 3-kinase inhibitor
Primary Target IC50 1.4 µM
Molar mass 307.4
Protect from Light Yes
Cell permeable Yes
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C19H17NO3
CAS number 154447-36-6
Store and ship information
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
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