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LY 294002
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4 µM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460 kDa phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50 µM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis. Shown to bind to the same site as I-BET (#401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~ 10 µM). A 10 mM (1 mg/325 µl) solution of LY 294002 (Cat. No. 440204) in DMSO is also available.
产品信息
Form Off-white solid
Primary Target specific phosphatidylinositol 3-kinase inhibitor
Primary Target IC50 1.4 µM
Molar mass 307.4
Protect from Light 是的
Cell permeable 是的
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C19H17NO3
CAS number 154447-36-6
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |