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7BIO
A cell-permeable 6-BIO (Cat. Nos. 361550 and 361552) structural isomer that acts as an ATP-competitive inhibitor of Flt3 (IC50 = 340 nM) and a caspase-independent, non-apoptotic cell death inducer (IC50 of cell survival ranges from 6.0 µM to 22.0 µM). Inhibition study against 75 other kinases reveals 10- to 80-fold selectivities over a group of 14 kinases, including TSF1, Aurora-A, and Aurora-B (IC50 = 3.3, 4.7, and 6.6 µM, respectively), up to 280-fold selectivities over a second group of 15 kinases, and little activity against the remaining 46 kinases of the panel (IC50 >100 µM).
产品信息
Form Deep black-red solid
Molar mass 356.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C16H10BrN3O2
CAS number 916440-85-2
商店和运输信息
Storage +2°C to +8°C
Ship Blue Ice Only
Regulatory Review |