|
IKK-3 Inhibitor IX
5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile
A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50 < 50 µM) 1A2, 2D6, 2C9, and 3A4.
产品信息
Form Beige solid
Molar mass 469.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C22H19N3O5S2
CAS number 862812-98-4
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful |