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产品说明
A cell-permeable β-carboline compound that displays anti-inflammatory properties. Acts as a potent, ATP-competitive, and reversible inhibitor of IKK (IC50 = 88 nM) with selectivity over 14 other commonly studied kinases (IC50 > 100 µM), including NF-κB inducing kinase. Blocks cellular IκBα phosphorylation and NF-κB activation (EC50 = 5 µM in TNF-α-treated HeLa cells) in vitro and reduces TNF-α release in plasma of LPS-challenged mice in vivo (50 mg/ml, p.o.).
产品信息
Form Yellow solid
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C17H11ClN4O
CAS number 431898-65-6
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
注：本产品仅用于生命科学研究实验，不作为任何药物及其他用途。 |