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产品说明
A cell-permeable piperidinyl-pyridine compound that acts as a selective inhibitor of IKK-2 activity (IC50 = 8.5 and 250 nM for IKK-2 and IKK-1, respectively) with little effect towards IKK-3, Syk, and MKK4 (IC50 >20 µM). Exhibits good aqueous solubility (0.12 mg/ml in pH 7.4 isotonic buffer) and potent activity in various cellular assays in vitro (IC50 <150 nM). Shown to be orally bioavailable both in rats and mice (BA = 60% and 16%, respectively) and effectively inhibit arachidonic acid-induced swelling in a murine ear edema model in vivo.
产品信息
Form Yellow solid
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C21H24N4O2
CAS number 406208-42-2
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Irritant
注：本产品仅用于生命科学研究实验，不作为任何药物及其他用途。 |