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Hydroxyfasudil
A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKβ, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
产品信息
Form Liquid
Formulation A 10 mM (2 mg/582 µl) solution in H2O.
Primary Target Rho-kinase
Primary Target IC50 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively
Molar mass 343.8
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
ATP Competitive 是的
Purity ≥98% by HPLC
Chemical formula C14H17N3O3S • HCl
CAS number 155558-32-0
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Harmful |