HISTONE DEACETYLASE 8, HIS*TAG, HUMAN RE

Histone Deacetylase 8, His•Tag®, Human Recombinant, S. frugiperda
Full length, recombinant, human histone deacetylase 8 (HDAC8) fused to at the C-terminus to a His•Tag® sequence at and expressed in S. frugiperda insect cells using a baculovirus expression system. HDAC8 phosphorylated in vivo by PKA results in decreased activity, which leads to the hyperacetylation of histones H3 and H4. HDAC8 may play a role in one of the most frequent types of acute myeloid leukemia (AML). The active deacetylase is useful in the study of HDAC8 regulation and for inhibitor screening.
产品信息
Form  Liquid
Formulation  In 138 mM NaCl, 25 mM Tris-HCl, 10% glycerol, 0.05% TWEEN®-20 detergent, pH 8.0.
Molar mass  46400
Avoid freeze/thaw  是的
Specific activity  ≥10 units/µg protein
Unit definition  One unit is defined as the the amount of enzyme required to deacetylate 1 picomol fluorescent peptide substrate [Arg-His-Lys(Ac)-Lys(Ac)] per min at 30°C.
Purity  ≥90% by SDS-PAGE
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Standard Handling