GANGLIOSIDE GM3, MONOSIALO, BOV. MILK

Ganglioside GM3, Monosialo, Ammonium Salt, Bovine Milk
Contains mainly N-acetylneuraminic acid. GM3 and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM3 is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC50 = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF. M.W. 1198.5 (based on stearoyl - 18:0).
产品信息
Form  White solid
Molar mass  1269.7
Purity  ≥98% by TLC
Solubility  Chloroform:MeOH (2:1)
Chemical formula  C64H118N2O21 · NH4
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Irritant