FOSTRIECIN, STREPTOMYCES PULVERACEOUS

Fostriecin, Sodium Salt, Streptomyces pulveraceous 
An antitumor antibiotic that acts as a potent protein phosphatase 2A (PP2A) inhibitor (IC50 = 3.2 nM). Inhibits protein phosphatase 1 (PP1) at much higher concentrations (IC50 = 131 µM). Does not affect the activity of protein phosphatase 2B (PP2B). Inhibits the catalytic activity of DNA topoisomerase II (topo II) and arrests cell growth at the G2/M phase of the cell cycle in a dose-dependent manner.
产品信息
Form  Colorless solid
Primary Target  PP2a
Primary Target IC50  3.2 nM
Secondary target  (PP1) at much higher concentrations (IC50 = 131 µM)
Molar mass  452.4
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥98% by HPLC
Solubility  EtOH, MeOH, or H2O
Chemical formula  C19H26O9PNa
RTECS  UQ0600000
CAS number  87860-39-7
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling