FORSKOLIN, COLEUS FORSKOHLII

Forskolin, Coleus forskohlii
The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes.
产品信息
Form  White to off-white crystalline solid
Molar mass  410.5
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C22H34O7
RTECS  QL6150000
CAS number  66575-29-9
Merck USA index 14, 2476
商店和运输信息
Storage  +15°C to +30°C
Ship  Ambient Temperature Only
Harmful
安全标示
S Phrase  S: 36
Wear suitable protective clothing.
R Phrase  R: 21
Harmful in contact with skin.