Forskolin, Coleus forskohlii The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. 产品信息 Form White to off-white crystalline solid Molar mass 410.5 Purity ≥99% by HPLC Solubility DMSO Chemical formula C22H34O7 RTECS QL6150000 CAS number 66575-29-9 Merck USA index 14, 2476 商店和运输信息 Storage +15°C to +30°C Ship Ambient Temperature Only Harmful 安全标示 S Phrase S: 36 Wear suitable protective clothing. R Phrase R: 21 Harmful in contact with skin.