COMBRETASTATIN A-4

Combretastatin A-4
NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII
A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
产品信息
Form  Off-white solid
Molar mass  316.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO or EtOH
Chemical formula  C18H20O5
CAS number  117048-59-6
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling
安全标示
S Phrase  S: 22-24/25-36
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.