CLODRONATE, DISODIUM SALT

Clodronate, Disodium Salt
Clodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
产品信息
Form  White solid
Molar mass  360.9
Hygrocopic  是的
Purity  ≥97% by titration
Solubility  H2O
Chemical formula  CH2Cl2O6P2Na2 • 4H2O
RTECS  SZ7640700
CAS number  22560-50-5
Merck USA index 14, 2371
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling