CL-387,785 N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide, EKI-785 A cell-permeable and irreversible inhibitor of EGF-receptor (EGFR) kinase activity in vivo (IC50 = 250-490 pM) as well as EGF-stimulated autophosphorylation of tyrosine residues in the EGFR in vivo (IC50 = 5 nM). Blocks EGF-mediated growth in A431 cells. Inhibits proliferation of EGFR or c-ErbB2 expressing cells (IC50 = 31-125 nM) by covalently binding to the EGFR. 产品信息 Form Pale yellow solid Primary Target EGFR kinase activity Primary Target IC50 5 nM Molar mass 381.2 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥95% by HPLC Solubility DMSO Chemical formula C18H13BrN4O CAS number 194423-06-8 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling