CCR2 Antagonist 2-((Isopropylaminocarbonyl)amino)-N-(2-((cis-2-((4-(methylthio)benzoyl)amino)cyclohexyl)amino)-2-oxoethyl)-5-(trifluoromethyl)-benzamide, CC Chemokine Receptor 2 Antagonist A cis-diamidocyclohexyl urea compound that potently competes against MCP-1 binding to CCR2 (IC50 = 5.1 nM) and effectively inhibits MCP-1/CCR2-mediated PBMCs Ca+2 flux and chemotaxis (IC50 = 18 and 1 nM, respectively), while showing much less effect against eotaxin binding to CCR3 (37% inhibition at 10 µM). Mutageneis analysis indicates CCR2 Thr292 is critical in maintaining the high affinity antagonist binding. 产品信息 Form White solid Molar mass 593.7 Protect from Light 是的 Hygrocopic 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC (racemic mixture) Solubility DMSO or EtOH Chemical formula C28H34F3N5O4S CAS number 445479-97-0 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling 安全标示 S Phrase S: 22-24/25-36/37/39 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection.