CFTR-F508del Corrector, KM11060 7-Chloro-4-(4-((4-chlorophenyl)sulfonyl)piperazino)quinoline A cell-permeable sulfonylpiperazine compound that is shown to boost the surface expression of cellular F508del-CFTR in a time- and dose-dependent manner and help restore CFTR function in F508del-CFTR-expressing cells (Effective concentration 10 µM). Evidence indicates that a correction of trafficking at the level of ER coupled with a transient increase of cellular cGMP due to PDEV (Cat. Nos. 524715 and 524738) inhibition as part of the cellular mechanism that accounts for the observed pharmacological effects of KM11060. 产品信息 Form White solid Molar mass 422.3 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥97% by HPLC Solubility DMSO Chemical formula C19H17Cl2N3O2S CAS number 774549-97-2 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling