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Cathepsin G, Human Neutrophil
Native cathepsin G from human neutrophil. A serine protease that degrades collagen and proteoglycans. Has been implicated in connective tissue diseases such as emphysema and rheumatoid arthritis. Acts as a potent agonist of human platelet activation leading to their aggregation. Reported to be involved in the activation of pro MMP-2 via mechanism requiring MT1-MMP. Inhibited by chymostatin, DFP, and Z-Phe-CH2Br. Reconstitute in 150 mM NaCl, 50 mM sodium acetate buffer, pH 5.5. Note: 1 mU = 1 milliunit.
产品信息
Form Salt-free lyophilized solid
Molar mass 23500
Specific activity ≥2 units/mg protein
Unit definition One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Suc-AAPF-pNA per min at 25°C, pH 7.5.
Purity ≥95% by SDS-PAGE
Source Prepared from blood that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
pH value optimum 7.5
Solubility 100mM NaCl, 50 mM Sodium acetate, pH 5.5.
EC number 3.4.21.20
CAS number 107200-92-0
Merck USA index 14, 1905
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |