CATHEPSIN S, HUMAN SPLEEN

Cathepsin S, Human Spleen
Native cathepsin S from human spleen. A major lysosomal cysteine proteinase that mediates degradation of MHC class II-invariant chain complexes in human and mouse antigen presenting cells. Cathepsin S secreted by activated macrophages has the ability to process myelin basic protein and amyloid β peptide which may be relevant to the pathogenesis of Alzheimer′s disease. It can hydrolyze elastin at both acidic and neutral pH. Note: 1 mU = 1 milliunit.
产品信息
Form  Lyophilized
Formulation  Lyophilized from 100 mM sodium acetate, 1 mM EDTA, pH 5.5.
Molar mass  24000
Avoid freeze/thaw  是的
Specific activity  ≥50 mU/mg protein
Unit definition  One unit is defined as the amount of enzyme that will hydrolyze Z-VVR-AMC in 10 min at 25°C, in 100 mM KPO4, 5 mM EDTA, pH 6.5 (the assay is standardized such that 0.041 nmol AMC gives a reading of 1000 RFU.
Purity  ≥90% by SDS-PAGE
Source  Prepared from tissue that has been shown by certified tests to be negative for HBsAg and for antibodies to HBC, HCV, and HIV.
Solubility  Aqueous buffers
EC number  3.4.22.27
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Standard Handling