β-Catenin/Tcf Inhibitor, FH535 N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide, Wnt Pathway Inhibitor IX A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action. 产品信息 Form Yellow solid Molar mass 361.2 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥94% by HPLC Solubility DMSO Chemical formula C13H10Cl2N2O4S CAS number 108409-83-2 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling