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Cdk1/2 Inhibitor II, NU6102
6-Cyclohexylmethoxy-2-(4′-sulfamoylanilino)purine
A cell-permeable 2,6-disubstituted purine compound that displays antiproliferative properties. Acts as a potent and ATP-competitive inhibitor of Cdk1/cyclin B and Cdk2/cyclin A3 (IC50 = 9.5 nM and 5.4 nM). Displays greater selectivity for Cdk1/2 over other kinases tested (IC50 = 600 nM, 800 nM, 900 nM and 1.6 µM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively). Shown to inhibit human MCF-7 breast carcinoma cell growth with a GI50 of 8 µM.
产品信息
Form White solid
Primary Target Cdk1/cyclin B, Cdk2/cyclin A3
Primary Target IC50 9.5 nM, 5.4 nM
Secondary target (IC50 = 600 nM, 800 nM, 900 nM and 1.6 mM for ROCKII, PDK1, DYRK1A and Cdk4/D1, respectively)
Molar mass 402.5
Protect from Light 是的
Packaged under inert gas 是的
ATP Competitive 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C18H22N6O3S
CAS number 444722-95-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Carcinogenic / Teratogenic |