Butein A cell-permeable, reversible, substrate competitive, plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 µM) and p60c-src (IC50 = 65 µM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and anti-inflammatory agent. Has been shown to inhibit glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM). Reported to activate sirtuins and promote the survival of eukaryotic cells. 产品信息 Form Yellow solid Primary Target tyrosine kinase activity of the EGF receptor Primary Target IC50 65 µM Secondary target p60c-src (IC50 = 65 µM), glutathione reductase and rat liver glutathione-S-transferase (IC50 = 9 µM) Molar mass 272.3 Protect from Light 是的 Packaged under inert gas 是的 ATP Competitive 是的 Purity ≥98% by HPLC Solubility DMSO or MeOH Chemical formula C15H12O5 CAS number 487-52-5 商店和运输信息 Storage -20°C Ship Ambient Temperature Only Standard Handling