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(+)-Brefeldin A, Eupenicillium brefeldianum
1,6,7,8,9,11a,12,13,14,14a-Decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis or lysosome function. Inhibitor of HDL-mediated cholesterol efflux. Causes disassembly of the Golgi complex and ER swelling in a variety of mammalian cell lines at <40 ng/ml. Blocks binding of ADP-ribosylation factor to the Golgi and inhibits the GDP-GTP exchange. Inhibits the activity of BIG1 and BIG2, the guanine-nucleotide exchange proteins for ADP-ribosylation factors.
产品信息
Form White crystalline solid
Molar mass 280.4
Purity ≥95% by HPLC
Solubility MeOH
Chemical formula C16H24O4
RTECS GY8410000
CAS number 20350-15-6
Merck USA index 14, 1369
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Harmful
安全标示
S Phrase S: 36
Wear suitable protective clothing.
R Phrase R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed. |