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Bcr-abl Inhibitor II
5-[(4-fluorobenzoyl)amino]-2-[(4-fluorobenzyl)thio]-1,3,4-thiadiazole, Abl Inhibitor II
A cell-permeable thiadiazole compound that acts as an ATP binding site-targeting inhibitor of Abl and c-Src kinases (Ki = 44 and 354 nM, respectively). Effectively inhibits cellular Bcr-Abl Tyr245 phosphorylation and the clonogenic activity of Bcr-Abl-transformed 32D cells, regardless of their resistance to Imatinib/STI571.
产品信息
Form White solid
Molar mass 363.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C16H11F2N3OS2
CAS number 607702-99-8
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling |