BAICALEIN 产品信息 Form Yellow solid Primary Target 12-lipoxygenase Primary Target IC50 120 nM Cell permeable 是的 Purity ≥98% by TLC Chemical formula C15H10O5 CAS number 491-67-8 Merck USA index 14, 942 Storage -20°C Ship Blue Ice Only Irritant 产品说明 A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.