AY 9944 A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (Δ7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts. 产品信息 Form White solid Primary Target Δ7-sterol reductase Primary Target IC50 13 nM Molar mass 464.3 Hygrocopic 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥95% by HPLC Solubility DMSO or H2O Chemical formula C22H28Cl2N2 • 2HCl RTECS GU7025000 CAS number 366-93-8 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Harmful & Carcinogenic / Teratogenic