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Autophagy Inducer, STF-62247
N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
A cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
产品信息
Form Beige solid
Molar mass 267.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C15H13N3S
CAS number 315702-99-9
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Toxic
安全标示
S Phrase S: 26-39
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear eye/face protection.
R Phrase R: 22-41
Harmful if swallowed.
Risk of serious damage to eyes. |