A cell-permeable tetracyclic diterpene antibiotic that acts as a cell synchronization agent. Blocks the cell cycle at early S-phase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses. Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines. Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3. Form White solid Primary Target DNA polymerase α, DNA polymerase δ Cell permeable 是的 Purity ≥98% by TLC Chemical formula C20H34O4 RTECS PB9185000 CAS number 38966-21-1 Merck USA index 14, 727 Aphidicolin 凋亡作为一种正常的细胞生物学行为，其研究需要一系列严格的实验程序，这可以通过多种诱导剂刺激细胞膜受体或激活线粒体调亡途径来诱导细胞的凋亡。